Cover L’Oreal For Women in Science Malaysia 2024 winner Dr Wong Sok Kuan is revolutionising osteoporosis treatments (Photo: L’Oreal For Women in Science)

L’Oreal For Women in Science Malaysia 2024 winner Dr Wong Sok Kuan is revolutionising osteoporosis treatments—merging science and collaboration to tackle complex healthcare challenges

The most remarkable careers often begin with unplanned detours. For Dr Wong Sok Kuan, scientific research wasn’t the intended destination.

“I actually never planned on a career in scientific research,” says the assistant professor at Universiti Kebangsaan Malaysia’s (UKM) Department of Pharmacology. But hands-on exposure during her biochemistry studies changed everything. What started as curiosity evolved into a passion for probing the molecular mechanisms of human health. “I saw firsthand how even small breakthroughs in the lab could eventually translate into real-world benefits, and that realisation motivated me to pursue a PhD and delve deeper into biomedical research.”

As each experiment revealed new possibilities in metabolic disorders and bone health, Wong was determined to use science-based solutions to address complex healthcare challenges. Now, as a L’Oréal-UNESCO For Women in Science Malaysia 2024 awardee, her pioneering work is set to transform the way we understand and treat diabetes-induced osteoporosis.

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Above Wong believes that building international networks and collaborations as a homegrown researcher can be one of the biggest challenges (Photo: Unsplash)

At the heart of Wong’s research lies an ambitious goal: redefining how diabetes-related bone loss is treated. “Right now, diabetes and osteoporosis are managed separately with medications targeting each condition,” she explains. “By targeting Glycogen Synthase Kinase-3 Beta (GSK3), we’re looking at a potential ‘master switch’ that regulates inflammation, connecting blood glucose control and bone metabolism.”

This approach could lead to earlier diagnosis and more effective treatments, tackling not just bone loss but the root causes linked to insulin resistance and inflammation. From fewer fractures and lower healthcare costs to an improved quality of life for Malaysia’s ageing population, the impact of this could be profound.

Overcoming the challenges of scientific discovery

For Wong, one of the biggest challenges was integrating the complexities of bone health, immunity, and metabolism. Research is rarely straightforward—and failure is often a given. “Each aspect comes with its own intricacies, and bringing them together required learning from experts across several fields.”

The ever-present battle for funding was—and is—also a challenge. “Long-term projects need diverse funding sources. I actively apply for government and private grants, emphasising translational potential and collaborating with industry partners.” Beyond finances, breaking into global scientific circles has its own hurdles. “As a homegrown researcher, building international collaborations can be difficult. I attend international conferences and join professional societies to create meaningful connections.”

Despite the grants she has received and the awards under her belt—including being ranked as a Top 2 per cent Scientist in the world by Elsevier for three consecutive years from 2020 to 2022—Wong was certainly not immune to imposter syndrome and self-doubt early in her career, a familiar adversary for many women in STEM.

“Positive thinking was key to overcoming my lack of confidence. I plan my research in small, strategic steps, build peer support, and adopt a growth mindset. Failures and setbacks happen, but they’re stepping stones, not roadblocks,” she says.

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Above Dr Wong Sok Kuan is assistant professor at Universiti Kebangsaan Malaysia’s (UKM) Department of Pharmacology at the Faculty of Medicine

What’s next for Wong? “My focus is twofold: deepening our understanding of immune modulation in bone metabolism and collaborating with industry and clinical partners to bring these findings from bench to bedside.” Beyond scientific breakthroughs, Wong hopes to nurture the next generation of researchers. “I want to inspire others to pursue impactful research and contribute to a healthier future through science-based solutions.”

Women in STEM face well-documented challenges, from securing funding to gaining recognition. “Early in my career, I had to juggle multiple roles—teaching, research, and community service—while trying to build credibility.” Wong believes initiatives such as the L’Oréal-UNESCO For Women in Science programme are game-changers for female scientsts, providing both financial support and visibility. “Recognition opens doors to collaborations and discussions with mentors and peers I wouldn’t have met otherwise. When strong partnerships come together, they empower researchers to push boundaries and inspire future generations.”

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For young women aspiring to biomedical research, Wong’s advice is clear: “Seek out hands-on learning opportunities—internships, lab work, research assistantships—because real experience can spark true passion.” In the field of scientific research in healthcare, never underestimate the power of mentorship and collaboration, especially as a young researcher. “Science thrives on teamwork. Connecting with fellow researchers and support programmes can fast-track both research and personal growth.”

Setbacks are part of the scientific process, and Wong has had her share. “Experiments fail. Hypotheses don’t always pan out. But each failure teaches something new. The process might be tough, but it often leads to better questions and, ultimately, better solutions.” Throughout the journey, perseverance and adaptability have become her guiding principles. “Even if you don’t ‘win’ every time, you still grow—and that growth lays the groundwork for your next breakthrough.”

Front & Female Changemakers celebrates the extraordinary journeys of inspiring women who have emerged as powerful changemakers in a range of fields, offering a glimpse into their lives and showcasing their courage, vision and relentless pursuit of change and progress. From social entrepreneurs and business leaders to educators, artists, activists and scientists, Front & Female changemakers exemplify the ability to challenge the status quo and demonstrate the power of women to effect change.

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